In 2077 AD, a mysterious virus called "Entropy Break" suddenly broke out and swept the world at an alarming rate. It not only takes away countless lives, but also causes infected people to mutate into irrational and terrifying creatures. The civilized world instantly collapses and order is lost. Nie Xingjin managed to survive the virus outbreak, but his body also mutated due to exposure to the virus. He struggled to survive in the ruins of the destroyed city and witnessed the greed, selfishness and brilliance of human nature. He accidentally discovered that the "entropic crack" virus did not seem to be naturally formed, and there may be a huge conspiracy hidden behind it. In order to explore the truth and find a glimmer of hope in this doomsday, Nie Xingjin embarks on a journey full of danger and unknowns. He will meet, cooperate, and confront other survivors, and write his own survival legend under the shadow of the era of entropy.