Dongfang Chuming, burdened by the vendetta that wiped out his family, and Zhao Yunchen, a fallen genius afflicted with an ancient, strange poison, are bound by the deadly link between the poisons in their bodies, which both nurture and counteract each other. As they investigate the truth and seek an antidote to survive, they fight conspiracies and the constraints of their cultivation arts. In the end, they rise from the ashes through poison and join hands to soar above the heavens.