Su Wantang, a modern Chinese medicine student, falls off a cliff and travels back to the ancient wandering mute woman. She was thrown into the wilderness by a poisonous mute after witnessing a murder. Relying on modern medical science and her original poisonous memory, she started selling medicine on the street to survive, and solved unsolved cases in the world with the medical skills of "one shot to calm the shock", and was involved in the twenty-year grudge between the "Jiuyi Sword Sect" and the "Ten Thousand Poison Sect". The cold-faced swordsman Gu Chenzhou, in order to find out the truth about his master's murder case, worked with her from being wary of each other to investigating the case side by side. In solving the puzzles such as "Qixiang Powder Serial Poison Murder" and "Hantan Bone Case", he gradually uncovered the mystery of Su Wantang's life experience as a "poisoner and doctor" - she was actually the orphan of the "Qingji Medical Valley" who was exterminated that year, and all conspiracies pointed to the mysterious forces trying to subvert the martial arts. In the end, Su Watang used medical skills to resolve the feud in the world, and Gu Chenzhou used his sword to protect the righteousness in his heart. After finding out the truth, the two of them found a new world path in troubled times by combining medicine and sword.
