The story is set in Yuncheng, a city near the river south of the Yangtze River. The Lu family, a centuries-old drug dealer, has a 20-year feud with the warlord Shen family. This background is full of intrigues and conflicts of interest. It starts with the encounter between Lu Zhiwei and Shen Yan and revolves around ancestral medical classics, family secrets, revenge plans, etc. There are not only the rising emotions and conflicts between the two people, but also the overt and covert struggles of the family forces.