The story is set in Yuncheng, a waterside city in Jiangnan. The Lu family, a century-old family of herbal medicine merchants, and the warlord Shen family have been locked in a feud for twenty years. Against this backdrop of power plays and competing interests, Lu Zhiwei and Shen Yan's meeting sets the story in motion. Their tale unfolds around an ancestral medical text, family secrets, and plans for revenge, blending the growing affection and conflicts between the two with the families' open and covert struggles for power.