In the fifty-ninth year of Kangxi, Shen Meizhuang was reborn on the eve of the draft. The murderous family letter and the blood-stained handkerchief on her pillow dragged her into a deeper whirlpool. In order to break the deadlock, she and the imperial physician Wen Shichu staged a fake pregnancy mystery, but they glimpsed the secrets of the previous dynasty in the epidemic prescription. When the clear water where the blood was dropped to test the relationship took on a strange color, and the golden needles at the bottom of the lotus pond were quenched with poison, the two of them played with their lives as a chess piece. And in the misty rain in the south of the Yangtze River, where the medicine pestle sounds softly, will old friends meet again?