Lu Yun'er, a modern orphan, accidentally traveled to the Ming Dynasty and became the second young lady of the Prime Minister's Mansion who lived abroad. She disguised herself as a man since she was a child, studied medicine and sold medicine with her adoptive parents among the people, and had a smart and tenacious personality.
When he was young, Lu Yun'er and Gu Changqing (the future second prince), who had not yet been confirmed as the prince, accidentally rescued Xie Yanzhou, the young master of the martial arts alliance who was seriously injured and fled in the mountains and forests. Xie Yanzhou was young, aloof and stubborn, so he gave Lu Yun'er his life-saving dagger as a token. From then on, he regarded her as his brother and never left her. A few years later, the three of them grew up individually, and their destinies intertwined again.