In an ancient town in southern Hunan, a dutiful doctor who had never once visited his father's grave returns home to pay his respects. There, a wrongfully murdered young woman entrusts him with a plea: Tang Yangjun must clear her name and avenge her. She gives him a mysterious package, and soon a vicious evil spirit comes after him, determined to take it back. A series of supernatural events follows. To protect the evidence, Tang Yangjun is relentlessly pursued by vengeful ghosts until he has nowhere left to turn. He flees through the night with his wife and son, without any particular destination, and reaches a mysterious old town. There, he practices medicine and cultivates his spiritual abilities. After spending several years learning from a master deep in the mountains, his ghost-hunting skills improve. To fulfill the last wishes of his father and the wrongfully murdered young woman, he waits for his chance and returns to the modern world to confront the evil spirit. Cruel, cold-hearted, and utterly wicked, it has committed every kind of atrocity and unleashed countless vengeful ghosts to plague the living. One bizarre and grisly supernatural case after another unfolds in the ancient towns of southern Hunan.