In the third year of Kaixi of the Southern Song Dynasty (1207), Yang Poyun, a descendant of the Yang family, became a fugitive because his father was involved in the Northern Expedition. While tracing the truth behind the family's destruction, he ran into Zhao Qinghui, a medical woman with a strange seven-star tattoo. The two discovered that the "Seven Days of Soul-Destroying" plague that broke out in Lin'an City was actually a shocking conspiracy planned by the powerful Prime Minister Shi Miyuan in collusion with the Kingdom of Jin.
As the investigation deepens, the seven-star tattoo leads to the mystery of the sudden death of Prince Xian twenty years ago. Zhao Qinghui's rotting tattoos are not only related to the bloodline of the Khitan royal family, but also resonate with the lost tiger charm of the Guangzong Dynasty. From Yaowang Valley to Shibo Division, from the Ancient Tea Horse Road to the Imperial City Underground Palace, confidential documents such as "Forbidden Prescriptions of the Imperial Medical Bureau" and "Shibo Secret Files" hidden in every official office point to the Shi Miyuan Group's regicide plan to usurp the country by secretly injecting poison into the country's lifeblood such as armaments, water transportation, and minting.