When the thousand-year-old snow on the top of Cangwu Mountain turned into a rain of blood, the star pattern on Su Yan's back, an apprentice at the medicine shop, began to burn. The fate of the ancient star official's reincarnation, the evil spirits whispering in the Nine Netherworld, and the twenty-eight Tiangang seals disintegrated one after another. From the Xuanming heavy water condensed by the tears of the South China Sea sharks to the Zhoutian star map hanging upside down on the top of Kunlun Ruins, the young people carrying the destiny of the Four Symbols gradually discovered that to restart the demon-sealing formation, not only artifacts are needed, but also the souls of the reincarnations of the stars as sacrifices.
The Nanming Lihuo in Qingluan Taoist's sleeves reflects the oath on the Sansheng Stone, and the cracks on Young Master Xuanming's carapace record the three thousand years of watching by the Xuanwu clan. And in the torn between the memory of the stars and human nature, Su Yan must make a choice that shakes the three realms - whether to become the Kuimu Langxing Lord who forever watches the stars in the sky, or to be the mortal pharmacist who will shed tears for the common people.