Lin Xia, a modern female forensic pathologist, transmigrates to the Great Liang dynasty after a car accident and becomes a disgraced empress banished to the Cold Palace. Faced with an unfamiliar palace and a tangled struggle for power, she uses her exceptional medical skills and modern forensic knowledge to gain a foothold in the perilous harem.
In the Cold Palace, she meets Prince Xiao Yu, who has been poisoned with a rare toxin. The two go from distrust to working together, uncovering one palace conspiracy after another. Lin Xia uses her professional expertise not only to save Xiao Yu, but also to earn the emperor's respect and return to the center of power.
But as her investigation deepens, she discovers that the empress dowager has joined forces with powerful court officials to plot a rebellion. Lin Xia and Xiao Yu join forces and begin plotting their counterattack. In this gripping struggle for power, Lin Xia must face attacks from every direction while choosing between love and power.