When the ECG monitoring in the emergency room became Emperor Chongzhen's call to arms, a medical murder spanning four hundred years was fermenting in the cracks of history. Lu Zhaoyang, a master surgeon, travels through the late Ming Dynasty in a car accident, and his medical box becomes quantumly entangled with a blood-stained sapphire bead. He was forced to be involved in a shocking conspiracy: the smallpox virus infected with nanometals was spreading in the capital, the secret files of Dongchang recorded his identity as a modern doctor, and the ECG monitoring of Emperor Chongzhen, who was hanging upside down on the crooked tree in Meishan, was actually connected to the operating table of the 21st century.