Regional economic spatial layout is the spatial distribution state of economic factors. It is not only the spatial expression of the laws of economic development, but also reflects the government's economic development intentions. Optimizing regional economic spatial layout will have an important impact on the quality of my country's economic development. We should implement the new development concept of innovation, coordination, green, openness and sharing, adhere to innovation-driven development to enhance the modernization level of the regional industrial chain; adhere to coordination and complementarity to enhance the resilience of regional economic development; adhere to green win-win and improve regional sustainable development capabilities; adhere to open competition and activate regional development vitality; adhere to sharing and integration to achieve common regional prosperity. Regional economic spatial layout is the spatial distribution state of economic factors, which is closely related to the resource endowment and location conditions of different regions, and is inseparable from government regulation and market regulation. The current optimization of regional economic spatial layout is not only a need for high-quality regional economic development, but also a need for building a new development pattern. During the "14th Five-Year Plan" and in the future period, we should give full play to the role of the government and the market in optimizing the layout of basic industries such as energy resources, manufacturing layout, ecological resource layout, and public resource layout. We should give full play to the role of the government and the market to improve relevant policies and institutional mechanisms, promote the further optimization and improvement of regional economic spatial layout, and provide important support for the formation of a new pattern of land and space development and protection and the promotion of high-quality development.