Gu Yi was born into a family of immortal physicians. Gifted and intelligent, he was obsessed with the way of the sword. He was once the person in the Sword Sect of the Gu Yue Continent with the best chance in a thousand years of breaking through the void and becoming a "Sword Immortal." But he was framed by his fellow sect members and betrayed by his beloved. Though he narrowly survived, his meridians were damaged. From then on, his temperament changed drastically. He indulged himself in worldly pleasures, and his cultivation plummeted. Later, with his friend Ling Cheng steadfastly by his side, he devoted himself to the way of medicine. When the ruins of the universe opened, a fortunate twist of fate led him to the Heavenly Spirit Pill. His spiritual meridians recovered, but he was left with pill poison, forcing him to cultivate both medicine and poison. After countless brushes with death, just as he was about to ascend, the Blood Demon emerged and demons ran rampant. Out of compassion for all living beings, Gu Yi used his body as a shield and his flesh and blood as a formation, sealing the Blood Demon beneath Mount Jue Ming.