Invasion of the Colossal Beasts

…

“What is real, and what is false? What exactly is the world we live in?”

“You want to know?”

“I do!”

“Then I'll take you to see.”

“Where?”

“To the other side of the Milky Way.”

…

One female lead + comedy and pop-culture references. No clichés, and don't worry, there are no tragic twists in the whole story.