Choose to Hold Hands, Protect Each Other for Life tells the story of heart surgeon Nie Yusheng and his former lover, single mother Tan Jing, as they face fate together and ultimately find happiness. Single mother Tan Jing and her son Sun Ping, who has congenital heart disease, depend on each other. To save up for her son's surgery, Tan Jing works hard and lives frugally. Although life is difficult, she bears no resentment or bitterness. She remains independent and strong, cherishes her ordinary life, and raises Sun Ping to be sensible and sweet. Nie Yusheng is a heart surgeon preparing a surgical program to help children with congenital heart disease. He selects Sun Ping as its first beneficiary. When Nie Yusheng meets the family, he discovers that the child's mother is Tan Jing, his girlfriend from seven years ago. During the course of treatment, Nie Yusheng is still deeply drawn to the resilient, courageous beauty Tan Jing has developed over the years, and touched by Sun Ping's sweetness and good manners. Life and time put them both to the test, but also help them face their love with greater maturity. In the end, Sun Ping is successfully treated, Tan Jing builds a career of her own, and Nie Yusheng's surgical program is successfully expanded. At last, they find their happily ever after.