"Choose to Hold Hands and Protect Your Life" tells the story of cardiac surgeon Nie Yusheng and his former lover and single mother Tan Jing, who face their fate hand in hand and finally usher in a happy life. Tan Jing, a single mother, and her son Sun Ping, who suffers from congenital heart disease, are dependent on each other. In order to save money for her son's surgery, Tan Jing works hard and lives frugally. Although life is hard, Tan Jing has no resentment or dissatisfaction. He is still independent and strong. He cherishes his ordinary life and raises Sun Ping to be sensible and cute. Nie Yusheng is a cardiac surgeon who is preparing a surgical CM project to help children with congenital heart disease. Sun Ping was selected to become the first child to benefit. While seeking medical treatment, Nie Yusheng discovered that the patient's mother was Tan Jing, his lover seven years ago. During the treatment, Nie Yusheng was still deeply attracted by Tan Jing's beauty of resilience and bravery, and was also moved by Sun Ping's cuteness and sensibleness. Life and time have given both parties a test, allowing them to face each other's love more maturely. In the end, Sun Ping was successfully treated, Tan Jing started her own career, Nie Yusheng's CM project was successfully promoted, and they finally ushered in a happy ending.