Return to Ancient Times as a Physician is a suspense novel combining transmigration, romance, and palace intrigue. Lin Youran, a modern female doctor, is accidentally electrocuted to death, but her soul transmigrates to ancient times and becomes Su Youran, an illegitimate daughter pushed to the margins of her family. In an era when medicine is underdeveloped and women hold low status, she decides to use her modern medical knowledge to change her fate. But is there a greater secret behind Youran's transmigration?
In the prince's manor, Youran wins the trust and respect of the cold Prince Li Chenyi with her medical skills and intelligence, but also finds herself at odds with his principal consort, Zhao Wanqing. She also meets the mysterious medical mentor Han Zimo and begins learning ancient medicine. Yet undercurrents swirl through the manor, and the plots behind a series of strange illnesses gradually come to light. Youran is caught in a difficult situation, but uses her intelligence and medical skills to expose Zhao Wanqing and Murong Xue's schemes step by step.
As Youran secures her place in the palace, she discovers that the secret behind her transmigration is connected to a mysterious jade pendant and begins searching for a way back to the modern world. But while exposing a major palace conspiracy, she finds herself in mortal danger. Chenyi will do anything to save her, and their love grows stronger. Facing threats from outside forces together, they expose and stop a palace coup, becoming guardians of the realm.
Youran spends her later years happily in ancient times, and her love story with Chenyi becomes legendary. Yet before she dies, she passes her medical knowledge and wisdom down to future generations, hoping they will continue to advance medicine. Could there be an even deeper secret and meaning behind all this?